If you’re experiencing pain in your joints, muscles, or bones, you may be wondering when do you need an orthopedic surgeon? The answer to this question may not be as clear-cut as you think. There are a variety of factors …
This year we will be holding our annual science conference in San Diego California. We will be using our conference to highlight the importance of genetics and health testing to help you make more informed decisions. The location of this …
Paralogs can be used if we cannot identify an orthologous relationship between two proteins. We would look at each protein’s gene family and do a separate phylogenetic analysis for every gene family.
What does a cladogram represent?
A cladogram is …
We can use gene duplication and loss to determine if our proteins are related or not. If there are two genes in a cluster but one of them is missing, it means that they recently diverged from each other. If …
This information can be used by an algorithm called BLAST, which finds all proteins that are similar to each other and groups them together into “clusters”.
From here, we can assume that the sequences in each cluster evolved together. Once …
There are two main types of errors that can occur in this process: false positive and false negative. A false positive occurs when two proteins are incorrectly found to be homologous, while a false negative occurs when one protein is …
A set of protein fragments (e.g., sequence motifs) present in multiple proteins. Each of these protein fragments is called an “aligned feature”, and the process by which they are discovered is called “feature discovery”.
The problem of finding all aligned …